RNA Details
Disease Name
pulmonary hypertension
Tissue
lung
RNA Symbol
mir-130a
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
qRT-PCR; Transient Transfection Of HPASMC etc.
Target
Cdkn1a
Pathway
NA
PubMed ID
Title
The hypoxia-induced microRNA-130a controls pulmonary smooth muscle cell proliferation by directly targeting CDKN1A
Year
2015
Function
"In hypoxia-induced PAH, miR-130 in upregulated. MiR-130 promote pulmonary smooth muscle cell proliferation by targeting CDKN1A, contributing to pulmonary vascular remodeling and right heart failure."